• Der Internist · Mar 2018

    Case Reports

    [Severe atypical ketoacidosis due to SGLT2-inhibitor therapy : Two case reports].

    • T G K Breuer, K Kampmann, A Wutzler, C Steinfort, W Uhl, W E Schmidt, and J J Meier.
    • Diabetes-Zentrum Bochum/Hattingen, Katholisches Klinikum Bochum, Klinikum der Ruhr-Universität Bochum, Gudrunstr. 56, 44791, Bochum, Deutschland.
    • Internist (Berl). 2018 Mar 1; 59 (3): 282-287.

    AbstractTwo female patients were admitted due to ketoacidosis. Serum glucose was moderately elevated. The patients exhibited abdominal and neurologic symptoms. Treatment consisted of metformin, insulin glargin and empagliflozin, as well as glimepiride, insulin detemir and empagliflozin, respectively. Treatment with intravenous fluid replacement, insulin, glucose, potassium and buffer solution led to a normalisation of pH and serum glucose levels. Our report describes two cases of atypical ketoacidosis with moderately elevated serum glucose during sodium-glucose co-transporter-2 (SGLT2) inhibitor therapy.

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