• Damien Mandry, Françoise Lapicque, Freddy Odille, Wassila Djaballah, Andrei Codreanu, Jean-Marie Escanyé, Jacques Felblinger, Gilles Karcher, Michel Claudon, and Pierre-Yves Marie.
• INSERM, ERI13 Imagerie Adaptative Diagnostique et Interventionnelle, Nancy, France. d.mandry@chu-nancy.fr
• J Magn Reson Imaging. 2009 Jan 1; 29 (1): 78-85.

PurposeTo analyze the relationship between late contrast enhancement (LCE) and the interstitial distribution volume (V(In)) of gadolinium (Gd) tracers in the myocardial infarction (MI) areas supplied by chronically occluded arteries from patients. In animal experimental models, LCE has already been shown to correspond to an enhanced V(In) of Gd tracers and thus, to a decrease in the amount of intact cells.Materials And MethodsA multicompartmental analysis was applied to serial MRI images encompassing both infarct and remote areas and recorded with a conventional two-dimensional (2D) segmented inversion-recovery gradient-echo (IR-GRE) sequence during a 15-minute period following Gd-diethylenetriamine pentaacetic acid (Gd-DTPA) injection in 12 patients with Q-wave MI supplied by chronically occluded coronary arteries.ResultsV(In) from infarct tissue was: 1) higher than V(In) from remote areas (in % of myocardial volume: 74 +/- 16% vs. 20 +/- 7%, P < 0.001); and 2) correlated with the quantification of LCE between infarct and noninfarct areas at the 15th minute (R(2) = 0.63, P = 0.002). However, the difference in V(In) between infarct and remote myocardium was a much better correlate of this quantified LCE (R(2) = 0.85, P < 0.001).ConclusionDetection of LCE in the MI territories supplied by chronically occluded arteries relates to the difference in the V(In) of tracers between the infarct and the noninfarct areas.

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