• The Laryngoscope · Jul 2009

    Review Case Reports

    Diagnostic and surgical dilemmas in hereditary medullary thyroid carcinoma.

    • Shawn M Allen, Donald Bodenner, James Y Suen, and Gresham T Richter.
    • Department of Otolaryngology-Head and Neck Surgery, University of Arkansas Medical Sciences, Little Rock, Arkansas, USA.
    • Laryngoscope. 2009 Jul 1; 119 (7): 1303-11.

    AbstractMedullary thyroid carcinoma (MTC) is a rare malignancy arising from the parafollicular C cells within the thyroid gland. The majority of cases are sporadic, but at least 30% are hereditary in nature. Inherited forms of MTC occur as familial MTC or as a manifestation of multiple endocrine neoplasia type 2. Early diagnosis and aggressive surgical management, including prophylactic thyroidectomy, improve the prognosis of patients with hereditary MTC. Several issues regarding the diagnosis and treatment of MTC remain controversial. Genetic penetrance and virulence are variable. We present an index case of familial MTC to illustrate common difficulties in the initial diagnosis and dilemmas in the surgical approach, followed by a review of current literature relevant to the management of hereditary MTC.

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