• Am. J. Surg. · Oct 2006

    Breast cancer-specific mortality after invasive local recurrence in patients with ductal carcinoma-in-situ of the breast.

    • Laura A Lee, Melvin J Silverstein, Cathie T Chung, Heather Macdonald, Premal Sanghavi, Melinda Epstein, Dennis R Holmes, Howard Silberman, Wei Ye, and Michael D Lagios.
    • Keck School of Medicine, University of Southern California, Los Angeles, CA 90033-0800, USA. lalee1061@gmail.com
    • Am. J. Surg. 2006 Oct 1; 192 (4): 416-9.

    BackgroundPrevious studies on the efficacy of primary treatments for ductal carcinoma-in-situ (DCIS) have focused on local recurrence rates. Our objective was to detail the outcomes of local invasive recurrence, distant recurrence, and breast cancer mortality in patients previously treated for DCIS.MethodsClinical, pathologic, and outcome data were collected prospectively for 1236 patients with pure DCIS accrued from 1972 through 2005.ResultsThere were 150 recurrences (87 DCIS and 63 invasive). Invasive local recurrence after mastectomy was rare (0.5% of patients) and after breast preservation was more frequent (12.0% of patients). The 12-year probabilities of breast cancer-specific mortality after mastectomy and after breast preservation were 0.8% and 1.0%, respectively. The 12-year breast cancer-specific mortality and distant disease probability for the 63 patients with invasive recurrences were 12% and 15%, respectively.ConclusionsRegardless of initial treatment, most patients with invasive local recurrence after treatment for DCIS can be treated and cured.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…