• Bilun Gemicioğlu, Arzu Didem Yalçın, Yavuz Havlucu, Gül Karakaya, Levent Özdemir, Metin Keren, Sevim Bavbek, Dane Ediger, İpek Kıvılcım Oğuzülgen, Zeynep Ferhan Özşeker, and Ayşe Arzu Yorgancıoğlu.
• Department of Pulmonary Diseases, Cerrahpaşa Faculty of Medicine, İstanbul University-Cerrahpaşa, İstanbul,Turkey.
• Turk J Med Sci. 2021 Oct 21; 51 (5): 251625232516-2523.

Background/AimWe aimed to report outcomes of pregnant patients with asthma under omalizumab treatment and their infants in our country.Materials And MethodsPatients with asthma who received omalizumab for at least 6 months and at least one dose during their pregnancy were retrospectively evaluated using a questionnaire regarding their disease and therapy and the health of their infants.ResultsTwenty pregnant patients and their 23 infant’s data were analyzed. The mean delivery age was 31.8 ± 7.4 years. They received omalizumab for 28.9 ± 21.8 months. Eight (36.4%) patients showed exacerbation of the disease during pregnancy. Forced expiratory volume in 1 s (FEV1) and asthma control test (ACT) scores at the starting time of omalizumab administration, first month of the pregnancy, and after delivery were 71 ± 18%, 83.4 ± 10.5%, and 80.5 ± 13% (FEV1), and 11.9 ± 4.9, 20.2 ± 2.6, and 20.4 ± 2.2 (ACT), respectively. One patient gave birth to twin infants, two patients to two infants each in different years, and 17 to one infant each. Three (13%) infants had low birth weight and five (21.7%) were born prematurely. No congenital anomalies were detected. Seven (30.4%) infants presented atopic diseases during their life.ConclusionOmalizumab treatment during pregnancy seems to be safe for both patients and their infants.This work is licensed under a Creative Commons Attribution 4.0 International License.

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