• Feride Ayyıldız, Hilal Yıldıran, Nigar Afandiyeva, Özlem Gülbahar, and Oğuz Köktürk.
• Department of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, Ankara, Turkey.
• Turk J Med Sci. 2021 Oct 21; 51 (5): 252425332524-2533.

Background/AimThe aim of this study was to investigate the effect of vitamin D on the disease prognosis and biochemical parameters in patients with mild obstructive sleep apnea syndrome (OSAS).Materials And MethodsNineteen adult male individuals (18–65 years) who were diagnosed with mild OSAS after polysomnography and had low vitamin D levels were included in the study. Each week, patients took 50.000 IU Vitamin D3 supplementation for 8 weeks. Polysomnography, biochemical parameters FBG (fasting blood glucose), lipid profile (TG, TC, LDL-C, HDL-C, VLDL-C), calcium, phosphorus, parathormone, calcitonin, serum 25(OH)D, insulin, CRP, TNF-α, IL-6, and IL-10 of patients were evaluated at the beginning of study and at the end of the study. All assessments, including polysomnography, were repeated after 8 weeks.ResultsSerum vitamin D levels were initially 19.5 ± 5.01 ng/mL and increased to 41.8 ± 10.51 ng/mL (p < 0.001) at the end of the study. FBG, TC and HOMA-IR of the patients were significantly decreased (p < 0.05). CRP, TNF-α, IL-6, and IL-10 levels were also correlated with serum vitamin D levels (p < 0.05). There was a significant decrease in number of obstructive apneas, apneas a nd hypopneas, apnea index, hypopnea index, and apnea hypopnea index of the patients (p < 0.05).ConclusionAs a result, it is thought that vitamin D supplementation may have a positive effect on the disease prognosis of mild OSAS.This work is licensed under a Creative Commons Attribution 4.0 International License.

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