• Priya Ranganathan, Girish Chinnaswamy, Manju Sengar, Durga Gadgil, Shivakumar Thiagarajan, Balram Bhargava, Christopher M Booth, Marc Buyse, Sanjiv Chopra, Chris Frampton, Satish Gopal, Nick Grant, Mark Krailo, Ruth Langley, Prashant Mathur, Xavier Paoletti, Mahesh Parmar, Arnie Purushotham, Douglas Pyle, Preetha Rajaraman, Martin R Stockler, Richard Sullivan, Soumya Swaminathan, Ian Tannock, Edward Trimble, Rajendra A Badwe, C S Pramesh, and National Cancer Grid of India.
• Department of Anaesthesiology, Critical Care and Pain, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, Maharashtra, India. Electronic address: ranganathanp@tmc.gov.in.
• Lancet Oncol. 2021 Aug 1; 22 (8): e369e376e369-e376.

AbstractLow-income and middle-income countries (LMICs) have a disproportionately high burden of cancer and cancer mortality. The unique barriers to optimum cancer care in these regions necessitate context-specific research. The conduct of research in LMICs has several challenges, not least of which is a paucity of formal training in research methods. Building capacity by training early career researchers is essential to improve research output and cancer outcomes in LMICs. The International Collaboration for Research methods Development in Oncology (CReDO) workshop is an initiative by the Tata Memorial Centre and the National Cancer Grid of India to address gaps in research training and increase capacity in oncology research. Since 2015, there have been five CReDO workshops, which have trained more than 250 oncologists from India and other countries in clinical research methods and protocol development. Participants from all oncology and allied fields were represented at these workshops. Protocols developed included clinical trials, comparative effectiveness studies, health services research, and observational studies, and many of these protocols were particularly relevant to cancer management in LMICs. A follow-up of these participants in 2020 elicited an 88% response rate and showed that 42% of participants had made progress with their CReDO protocols, and 73% had initiated other research protocols and published papers. In this Policy Review, we describe the challenges to research in LMICs, as well as the evolution, structure, and impact of CReDO and other similar workshops on global oncology research.Copyright © 2021 Elsevier Ltd. All rights reserved.

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