• Eur. Respir. J. · Feb 2015

    Randomized Controlled Trial Multicenter Study Observational Study

    Effect of obstructive sleep apnoea on severity and short-term prognosis of acute coronary syndrome.

    • Ferran Barbé, Alicia Sánchez-de-la-Torre, Jorge Abad, Joaquin Durán-Cantolla, Olga Mediano, Jose Amilibia, Maria José Masdeu, Marina Florés, Antonia Barceló, Mónica de la Peña, Albina Aldomá, Fernando Worner, Joan Valls, Gerard Castellà, Manuel Sánchez-de-la-Torre, and Spanish Sleep Network.
    • Respiratory Dept, Hosp Universitari Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain febarbe.lleida.ics@gencat.cat.
    • Eur. Respir. J. 2015 Feb 1; 45 (2): 419-27.

    AbstractThe goal of this study was to evaluate the influence of obstructive sleep apnoea on the severity and short-term prognosis of patients admitted for acute coronary syndrome. Obstructive sleep apnoea was defined as an apnoea-hypopnoea index (AHI) >15 h(-1). We evaluated the acute coronary syndrome severity (ejection fraction, Killip class, number of diseased vessels, and plasma peak troponin) and short-term prognosis (length of hospitalisation, complications and mortality). We included 213 patients with obstructive sleep apnoea (mean±sd AHI 30±14 h(-1), 61±10 years, 80% males) and 218 controls (AHI 6±4 h(-1), 57±12 years, 82% males). Patients with obstructive sleep apnoea exhibited a higher prevalence of systemic hypertension (55% versus 37%, p<0.001), higher body mass index (29±4 kg·m(-2) versus 26±4 kg·m(-2), p<0.001), and lower percentage of smokers (61% versus 71%, p=0.04). After adjusting for smoking, age, body mass index and hypertension, the plasma peak troponin levels were significantly elevated in the obstructive sleep apnoea group (831±908 ng·L(-1) versus 987±884 ng·L(-1), p=0.03) and higher AHI severity was associated with an increased number of diseased vessels (p=0.04). The mean length of stay in the coronary care unit was higher in the obstructive sleep apnoea group (p=0.03). This study indicates that obstructive sleep apnoea is related to an increase in the peak plasma troponin levels, number of diseased vessels, and length of stay in the coronary care unit.Copyright ©ERS 2015.

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