• Melekşah Pekel, Nadide Aysun Postaci, İsmail Aytaç, Derya Karasu, Hüseyin Keleş, Özlem Şen, Bayazit Dikmen, and Erol Göka.
• Department of Anesthesiology and Reanimation, Private Deniz Hospital, İzmir, Turkey.
• Turk J Med Sci. 2016 Apr 19; 46 (3): 756-63.

Background/AimIn this prospective randomized cross-over study we compare the effects of sevoflurane versus propofol for electroconvulsive therapy (ECT) anesthesia.Materials And MethodsTwenty four patients (ASA I-III, 18-65 years old) receiving ECT three times per week were included. Anesthesia was induced with either propofol (0.75 mg/kg iv) or 5% sevoflurane in 100% oxygen. Consecutive ECT sessions followed a 2 × 2 crossover design and a 2-day washout period until the 10th ECT. Intravenous succinylcholine (1 mg/kg) was administered while bispectral index (BIS) values were ≤60%.ResultsElectromyogram and electroencephalogram seizure duration, postictal suppression index, BIS values, mean arterial blood pressure (MAP), heart rate, times to start of spontaneous respiration, eye opening, understanding verbal commands, and side effects were compared. No differences were found between the regimens for seizure activity and recovery. At the end of ECT, MAP was higher with sevoflurane. Although BIS values were higher after sevoflurane, no differences between the regimens were found in terms of the need of muscle relaxants and in hypnosis levels.ConclusionSevoflurane (5%) may be an effective alternative to propofol for induction of anesthesia for ECT.

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