• Clin. Exp. Dermatol. · Sep 1990

    Case Reports

    Orofacial granulomatosis associated with delayed hypersensitivity to cobalt.

    • D W Pryce and C M King.
    • Department of Dermatology, Royal Liverpool Hospital, UK.
    • Clin. Exp. Dermatol. 1990 Sep 1; 15 (5): 384-6.

    AbstractOrofacial granulomatosis is a distinct clinical and pathological entity characterized by swelling of the lips and lower half of the face. Ulceration of the oral mucosa may also occur. Granulomas are seen histologically. Orofacial granulomatosis may occur in the Melkersson-Rosenthal syndrome, granulomatous cheilitis of Miescher, oral Crohn's disease, sarcoidosis and focal dental sepsis. The increased prevalence of atopy in patients with orofacial granulomatosis and the association with food intolerance suggests the possibility of a role for allergy in at least some cases.

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