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Revue médicale suisse · Mar 2019
[Rheumatoid arthritis-associated interstitial lung disease : new genetic data and therapeutic perspectives].
- Flore Valerio, Cécile Daccord, Igor Letovanec, Thomas Hügle, and Romain Lazor.
- Service de rhumatologie, Département de l'appareil locomoteur, CHUV, 1011 Lausanne.
- Rev Med Suisse. 2019 Mar 6; 15 (641): 536-541.
AbstractDiffuse interstitial lung disease (ILD) is one of the most frequent extra-articular manifestation of rheumatoid arthritis (RA) and is an important factor of morbidity and mortality. However, the physiopathological mechanisms underlying RA-associated ILD remain poorly understood, and disease management is difficult in the absence of effective treatments and international guidelines. The recent identification of genetic variants and mutations similar to those observed in idiopathic pulmonary fibrosis (IPF), a disease affecting exclusively the lung, provides new insights into the understanding of RA-associated ILD. Furthermore, new antifibrotic drugs approved for the treatment of IPF, including pirfenidone and nintedanib, could also prove to be effective for RA-associated ILD. Studies are ongoing to confirm this hypothesis.
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