• Neurological research · Apr 2008

    Comparative Study

    Metabolite concentration ratios in thalami of patients with migraine and trigeminal neuralgia measured with 1H-MRS.

    • Tao Gu, Xiang-Xing Ma, Yan-Hong Xu, Jian-Jun Xiu, and Chuan-Fu Li.
    • Department of Radiology, Qilu Hospital of Shandong University, Jinan 250012, China. gutao001@sina.com
    • Neurol. Res. 2008 Apr 1; 30 (3): 229-33.

    ObjectiveTo investigate the metabolite concentration ratios including N-acetylaspartate (NAA), choline-containing compounds (Cho) and creatine plus phosphocreatine (Cr) in thalami of patients with migraine without aura, patients with trigeminal neuralgia and healthy comparison subjects using multi-voxel proton magnetic resonance spectroscopy (1H-MRS).Methods1H-MRS was performed with a 3.0 T MR system on the thalamus bilaterally in 20 patients with migraine without aura, 16 patients with trigeminal neuralgia and 14 healthy control subjects.ResultsIn the patients with trigeminal neuralgia, metabolite concentration ratios except for Cho/Cr in thalami were different from those of healthy subjects (p>0.05). In migraine group, only NAA/Cho is low in the left thalamus (p>0.05). Comparing the metabolite concentration ratios of affected and contralateral sides in migraine and trigeminal neuralgia groups, only NAA/Cr showed a significant difference (p>0.05).ConclusionIt was proved that migraine and trigeminal neuralgia seemed to be associated with an abnormal balance of the neural activity in the thalamus using 1H-MRS. There was some significant difference between metabolite concentration ratios in two diseases. 1H-MRS may serve as a useful non-invasive tool for evaluating thalamic neural activity and therapy effect in clinical performance of patients with migraine without aura.

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