• J. Pediatr. Hematol. Oncol. · Mar 2014

    Acute pain relief after Mantram meditation in children with neuroblastoma undergoing anti-GD2 monoclonal antibody therapy.

    • Mahiuddin Ahmed, Shakeel Modak, and Sonia Sequeira.
    • *Department of Pediatrics †Office of Clinical Research, Memorial Sloan-Kettering Cancer Center, New York, NY.
    • J. Pediatr. Hematol. Oncol. 2014 Mar 1; 36 (2): 152-5.

    AbstractNonpharmacologic, mind-body interventions are used to reduce anxiety in pediatric patients. Anti-ganglioside GD2 monoclonal antibody (anti-GD2 MoAb 3F8) therapy is the standard of care for high-risk neuroblastoma and pain is its major side effect. We performed a retrospective analysis of children undergoing anti-GD2 MoAb 3F8 treatment who received guided meditation. Meditation involved concentrating on the repetition of rhythmic, melodic sounds purported to slow breathing and induce a relaxation response. A total of 71% patients completed a session at first (n=19) or second attempt (n=5). Patients received fewer analgesic doses to manage anti-GD2 MoAb 3F8-induced pain when participating in meditation (n=17, mean=-0.4 dose, P<0.01). Mantram meditation is a feasible outpatient intervention associated with reduced analgesic requirements.

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