• The oncologist · Dec 2014

    Multicenter Study

    Frailty is an independent predictor of survival in older patients with colorectal cancer.

    • Nina Ommundsen, Torgeir B Wyller, Arild Nesbakken, Marit S Jordhøy, Arne Bakka, Eva Skovlund, and Siri Rostoft.
    • Institute of Clinical Medicine and Department of Pharmaceutical Biosciences, School of Pharmacy, University of Oslo, Norway; Departments of Geriatric Medicine and Gastrointestinal Surgery and Regional Centre for Excellence in Palliative Care, South-East Norway, Oslo University Hospital, Oslo, Norway; Departments of Geriatric and General Internal Medicine and Digestive Surgery, Akershus University Hospital, Lørenskog, Norway; Cancer Unit, Innlandet Hospital Trust, Hamar, Norway; K.G. Jebsen Colorectal Cancer Research Centre, Oslo, Norway ninaommundsen@gmail.com.
    • Oncologist. 2014 Dec 1; 19 (12): 1268-75.

    BackgroundColorectal cancer (CRC) is prevalent in the older population. Geriatric assessment (GA) has previously been found to predict treatment tolerance and postoperative complications in older cancer patients. The aim of this study was to explore whether GA also predicts 1-year and 5-year survival after CRC surgery in older patients and to compare the predictive power of GA with that of established prognostic factors such as TNM classification of malignant tumors (TNM) stage and age.Materials And MethodsA cohort of 178 CRC patients aged 70 and older were followed prospectively. All patients went through elective surgery, and GA was performed presurgery. The GA resulted in patients being divided into two groups: frail or nonfrail. All patients were followed for 5 years or until death. Data were analyzed by Kaplan-Meier plots and the Cox proportional hazards model.ResultsSeventy-six patients (43%) were frail, and one hundred and two (57%) were nonfrail. Twenty-three patients (13%) died during the first year after surgery. One-year survival was 80% in the frail group and 92% in the nonfrail group. Five-year survival was significantly lower in frail (24%) than nonfrail patients (66%), and this difference was apparent both within the stratums of TNM stages 0-II and TNM stage III. In multivariable analysis adjusting for TNM stage, age, and sex, frailty was an independent prognostic factor for survival.ConclusionA GA-based frailty assessment predicts 1-year and 5-year survival in older patients after surgery for CRC. In localized and regional disease, the impact of frailty upon 5-year survival is comparable with that of TNM stage.©AlphaMed Press.

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