• Acta Obstet Gynecol Scand · Jan 1979

    Randomized Controlled Trial Clinical Trial

    Bromocriptine treatment of the premenstrual syndrome.

    • S Kullander and L Svanberg.
    • Acta Obstet Gynecol Scand. 1979 Jan 1; 58 (4): 375-8.

    AbstractBromocriptine, 2.5 mg twice a day was tested for its effect on premenstrual tension in a random double-blind cross-over trial. 1. The compound tended to lessen the symptoms, especially mastodynia. 2. Serum prolactin levels around the upper limit of the normal range were significantly lowered. Patients with the highest starting prolaction levels had the most severe symptoms and in these patients the fall in the levels was greatest. 3. Serum FSH and LH levels were significantly reciprocally influenced compared with serum prolactin. Serum estradiol-17-beta and progesterone did not change during treatment. 4. The bromocriptine-treated cycles were all ovulatory according to basal temperature levels. The luteal phase was prolonged when serum FSH was raised.

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