• Oncology Ny · Nov 2000

    Review

    Role of oral chemotherapy in colorectal cancer.

    • R C Donehower.
    • Johns Hopkins Oncology Center, Baltimore, Maryland, USA.
    • Oncology Ny. 2000 Nov 1; 14 (11A): 243-5.

    AbstractDespite the long clinical history of 5-FU in gastrointestinal cancer, the development of oral agents has been a productive endeavor, and oral fluoropyrimidine agents are likely to play an important role in the management of colorectal cancer. Results of recent trials in advanced/metastatic colorectal cancer have shown equivalence of response rates, time to disease progression, and median survival and reduced rates of neutropenia and stomatitis with oral capecitabine (Xeloda) or UFT/leucovorin compared with standard fluorouracil (5-FU)/leucovorin regimens. Evaluation of these oral agents in adjuvant therapy, in combination chemotherapy, and in combination with radiation therapy is ongoing.

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