• Jan Petr, Georg Schramm, Frank Hofheinz, Jens Langner, and Jörg van den Hoff.
• PET Center, Institute of Radiopharmacy, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.
• Magn Reson Med. 2013 Dec 1; 70 (6): 1535-43.

PurposePartial volume (PV) effects are caused by limited spatial resolution and significantly affect cerebral blood flow investigations with arterial spin labeling. Therefore, accurate PV correction (PVC) procedures are required. PVC is commonly based on PV maps obtained from segmented high-resolution T1 -weighted images. Segmentation of these images is error-prone, and it can be difficult to coregister these images accurately with the single-shot ASL images such as those created by echo-planar imaging (EPI). In this paper, an alternative method for PV map generation is proposed.MethodsThe Look-Locker EPI (LL-EPI) acquisition is used for analyzing the T1 -recovery curve and for subsequent PV map generation. The new method was evaluated in five healthy volunteers (mean age 30 ± 3.7 years).ResultsBy applying a linear regression method for PVC, a 12% decrease in regression error was reached with the new method.ConclusionPV maps extraction from LL-EPI is a viable, possibly superior alternative to the standard approach based on segmentation of high-resolution T1 -weighted images.Copyright © 2012 Wiley Periodicals, Inc., a Wiley company.

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