• British journal of cancer · Feb 2015

    Evaluation of chemoresponse assays as predictive markers.

    • E L Korn and B Freidlin.
    • Biometric Research Branch, MSC 9735, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD 20892, USA.
    • Br. J. Cancer. 2015 Feb 17; 112 (4): 621-3.

    BackgroundA chemoresponse assay that can be used to predict which patients will respond to which drugs would be useful in directing treatment. Two new analytic methods to assess the predictive ability of a chemoresponse assay have been proposed by Tian et al.MethodsThree examples in which a hypothetical assay has no predictive ability are considered to evaluate the properties of the proposed analytic methods.ResultsFor these specific examples, the proposed methods incorrectly suggest that the assay is predictive.ConclusionsThe examples presented here demonstrate that it can be challenging to evaluate the predictive value of a chemoresponse assay.

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