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Kidney international · Dec 2017
ReviewThe promise of single-cell RNA sequencing for kidney disease investigation.
- Haojia Wu and Benjamin D Humphreys.
- Division of Nephrology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
- Kidney Int. 2017 Dec 1; 92 (6): 1334-1342.
AbstractRecent techniques for single-cell RNA sequencing (scRNA-seq) at high throughput are leading to profound new discoveries in biology. The ability to generate vast amounts of transcriptomic data at cellular resolution represents a transformative advance, allowing the identification of novel cell types, states, and dynamics. In this review, we summarize the development of scRNA-seq methodologies and highlight their advantages and drawbacks. We discuss available software tools for analyzing scRNA-Seq data and summarize current computational challenges. Finally, we outline ways in which this powerful technology might be applied to discovery research in kidney development and disease.Copyright © 2017 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.
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