• The Laryngoscope · May 2020

    Frailty as a predictor of outcomes in patients undergoing head and neck cancer surgery.

    • David P Goldstein, Michael C Sklar, John R de Almeida, Ralph Gilbert, Patrick Gullane, Jonathan Irish, Dale Brown, Kevin Higgins, Danny Enepekides, Wei Xu, Jie Su, and AlibhaiShabbir M HSMHDepartment of Medicine, University of Toronto, Toronto, Ontario, Canada..
    • Department of Otolaryngology Head and Neck Surgery/Surgical Oncology, Princess Margaret Cancer Center, University of Toronto, Toronto, Ontario, Canada.
    • Laryngoscope. 2020 May 1; 130 (5): E340-E345.

    ObjectivesTo evaluate whether frailty and functional measures are predictors of perioperative complications and length of hospital stay (LOS) in patients undergoing head and neck cancer surgery.Study DesignProspective study.MethodsPatients 50 years and older undergoing major head and neck cancer surgery between 2011 and 2015 preoperatively completed Fried's Frailty Index, Barthel Index, Lawton-Brody questionnaire and Vulnerable Elders Survey-13. Primary outcome measures were postoperative complications and LOS, which were analyzed using multivariable logistic and linear regression models.ResultsThere were 274 patients recruited (105 aged 50-64 and 169 aged 65 and older). Of these, 119, 132, and 23 were defined as non-frail, pre-frail, and frail, respectively. Frailty score and functional measures were not predictors of overall complications. In multivariable models, frailty score (odds ratio [OR] = 1.36; 95% confidence interval [CI], 1.04-1.78, P = .025) was a predictor of medical complications and Clavien-Dindo Grade III and higher complications independent of age and comorbidity. Higher frailty score (β = 1.07; 95% CI, 1.02-1.12, P = .0025) and less independence on the Lawton Brody (β = -0.08; 95% CI, -0.11 to -0.05, P < .001) and Barthel Index (β = -0.12; 95% CI, -0.19 to -0.06, P < .001) were predictors of increased LOS.ConclusionsFrailty was a predictor of type and severity of complications. Both frailty and measures of independence in activities of daily living were independent predictors of LOS. Frailty and functional assessment can help surgeons identify patients at risk of adverse postoperative outcomes and thus aid in counselling patients as well as identifying patients that may benefit from comprehensive geriatric assessment and targeted interventions.Level Of EvidencePrognosis study 2b Laryngoscope, 130:E340-E345, 2020.© 2019 The American Laryngological, Rhinological and Otological Society, Inc.

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