• Z Rheumatol · Oct 2020

    Review

    [Checkpoint inhibitors-indications and application in melanoma patients].

    • C Lamos and R E Hunger.
    • Universitätsklinik für Dermatologie, Inselspital Bern, Freiburgstr. 34, 3010, Bern, Schweiz. cristina.lamos@insel.ch.
    • Z Rheumatol. 2020 Oct 1; 79 (8): 818-825.

    AbstractSince its introduction in 2011 the checkpoint inhibitor ipilimumab, has revolutionized the whole of oncology. After this first major step more checkpoint inhibitors, such as the PD‑1 antibodies nivolumab and pembrolizumab have been developed. The results are groundbreaking, especially in advanced malignant melanoma, which only a few years ago led to certain death in most cases after only a few months. Currently, the application of checkpoint inhibitors has been extended to many more tumor entities, with very promising results.

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