• Heart Rhythm · Mar 2014

    Long-term follow-up after atrial fibrillation ablation in patients with impaired left ventricular systolic function: the importance of rhythm and rate control.

    • Sotirios Nedios, Philipp Sommer, Nikolaos Dagres, Jedrzej Kosiuk, Arash Arya, Sergio Richter, Thomas Gaspar, Nikolaos Kanagkinis, Borislav Dinov, Christopher Piorkowski, Andreas Bollmann, Gerhard Hindricks, and Sascha Rolf.
    • Department of Electrophysiology, Heart Center, University of Leipzig, Leipzig, Germany. Electronic address: Sotirios.Nedios@herzzentrum-leipzig.de.
    • Heart Rhythm. 2014 Mar 1; 11 (3): 344-51.

    BackgroundAtrial fibrillation (AF) ablation is increasingly used in patients with reduced left ventricular ejection fraction (LVEF), but long-term outcomes are still unknown.ObjectiveTo assess the long-term effects of AF ablation in patients with systolic heart failure according to rhythm outcome.MethodsWe included 69 patients with LVEF ≤40%, referred for circumferential pulmonary vein isolation with or without additional substrate modification to our institution in 2006-2010. Follow-up included 7-day Holter electrocardiography and echocardiography at baseline and at 6, 12, and 24 months after ablation. A matched control group (n = 69) after AF ablation without heart failure was used for comparison.ResultsAfter 28 ± 11 months and 1.6 ± 0.7 ablation procedures, 45 (65%) patients were still in the stable sinus rhythm (SSR) group. LVEF increased from 33 ± 6% to 53 ± 11% (P < .001) in the SSR group and from 33 ± 5% to 38 ± 12% (P = .03) in patients with recurrences (atrial tachycardia/fibrillation group). While LVEF increase was similar in the 2 groups at 6 months (15 ± 12% vs 8 ± 11%; P = .2), further LVEF improvements were observed in the SSR group only. Adjustments for baseline characteristics revealed that the increase in LVEF at 6 months was associated with higher baseline heart rate and not with rhythm outcome. Heart rate did not change in either group after 6 months of follow-up. Complications and procedural data of the study group were similar to the control group.ConclusionIn patients with heart failure undergoing AF ablation, there is an initial short-term LVEF improvement related to baseline heart rate. However, long-term LVEF improvement is associated with rhythm outcome.Copyright © 2014 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.

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