• Cirugía española · Jun 2016

    Axillary radiotherapy in conservative surgery for early-stage breast cancer (stage I and II).

    • Alejandra García Novoa, Benigno Acea Nebril, Inma Díaz, Sergio Builes Ramírez, Cristina Varela, Carmen Cereijo, Joaquín Mosquera Oses, Beatriz López Calviño, and Seoane PilladoMaría TeresaMTUnidad de Estadística y Epidemiología, Complejo Hospitalario Universitario de A Coruña, La Coruña, España..
    • Unidad de Mama, Servicio de Cirugía General y del Aparato Digestivo, Complejo Hospitalario Universitario de A Coruña, La Coruña, España. Electronic address: mag_1406@hotmail.com.
    • Cir Esp. 2016 Jun 1; 94 (6): 331-8.

    IntroductionSeveral clinical studies analyze axillary treatment in women with early-stage breast cancer because of changes in the indication for axillary lymph node dissection. The aim of the study is to analyze the impact of axillary radiotherapy in disease-free and overall survival in women with early breast cancer treated with lumpectomy.MethodsRetrospective study in women with initial stages of breast carcinoma treated by lumpectomy. A comparative analysis of high-risk women with axillary lymph node involvement who received axillary radiotherapy with the group of women with low risk without radiotherapy was performed. Logistic regression was used to determine factors influencing survival and lymphedema onset.ResultsA total of 541 women were included in the study: 384 patients (71%) without axillary lymph node involvement and 157 women (29%) with 1-3 axillary lymph node involvement. Patients with axillary radiotherapy had a higher number of metastatic lymph node compared to non-irradiated (1.6±0.7 vs. 1.4±0.6, P=.02). The group of women with axillary lymph node involvement and radiotherapy showed an overall and disease-free survival at 10 years similar to that obtained in patients without irradiation (89.7% and 77.2%, respectively). 3 lymph nodes involved multiplied by more than 7 times the risk of death (HR=7.20; 95% CI: 1.36 to 38.12). The multivariate analysis showed axillary lymph node dissection as the only variable associated with the development of lymphedema.ConclusionThe incidence of axillary relapse on stage I and II breast cancer is rare. In these patients axillary radiotherapy does not improve overall survival, but contributes to regional control in those patients with risk factors.Copyright © 2016 AEC. Publicado por Elsevier España, S.L.U. All rights reserved.

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