-
- N Ishizuka.
- Division of Cancer Information & Epidemiology, National Cancer Center Research Institute.
- Gan To Kagaku Ryoho. 2000 Aug 1; 27 (9): 1449-57.
AbstractWe discuss the basic concept of the continual reassessment method (CRM) and some modifications. The CRM has been proposed as alternatives of traditional cohort design for phase I trials in cancer. To focus on the dilemma between ethical concern and scientific purpose, we review the requirement for the phase I settings and the issues of the traditional cohort design. Then, CRM is introduced so that the essential feature is in the sequential (continual) selection of a dose level for next patients based on the dose-toxicity relationship and in updating the relationship based on patients' response date using Bayesian calculation. Finally we discuss both advantages and pitfalls in practice.
Notes
Knowledge, pearl, summary or comment to share?You can also include formatting, links, images and footnotes in your notes
- Simple formatting can be added to notes, such as
*italics*,_underline_or**bold**. - Superscript can be denoted by
<sup>text</sup>and subscript<sub>text</sub>. - Numbered or bulleted lists can be created using either numbered lines
1. 2. 3., hyphens-or asterisks*. - Links can be included with:
[my link to pubmed](http://pubmed.com) - Images can be included with:
 - For footnotes use
[^1](This is a footnote.)inline. - Or use an inline reference
[^1]to refer to a longer footnote elseweher in the document[^1]: This is a long footnote..