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J. Am. Acad. Dermatol. · May 2004
Dacarbazine but not temozolomide induces phototoxic dermatitis in patients with malignant melanoma.
- Regina Treudler, Juliana Georgieva, Christoph C Geilen, and Constantin E Orfanos.
- Department of Dermatology, Charité-University Medical School Berlin, Campus Benjamin Franklin, Berlin, Germany. regina.treudler@charite.de
- J. Am. Acad. Dermatol. 2004 May 1; 50 (5): 783-5.
AbstractTen patients with malignant melanoma and phototoxic reactions under dacarbazine or 5-(3,3-dimethyl-1-triazeno) imidazole-4-carboxamide (DTIC) chemotherapy were investigated. All patients available for testing showed increased ultraviolet A-sensitivity (n = 5); patch testing revealed no type IV allergies (n = 6). In 5 patients intravenous DTIC was replaced by oral temozolomide, and no phototoxicity occurred. Temozolomide may represent an alternative for patients with DTIC-induced phototoxic skin reactions.
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