• Gan To Kagaku Ryoho · Nov 2012

    Case Reports

    [A case of recurrent gastrointestinal stromal tumor with complete response from treatment with reduced dose of imatinib mesylate].

    • Takahiro Toyokawa, Yoshito Yamashita, Atsushi Yamamoto, Sadatoshi Shimizu, Tohru Inoue, Teruyuki Ikehara, Katsuya Sakashita, Isao Kanehara, Hitoshi Teraoka, and Yukio Nishiguchi.
    • Dept. of Surgery, Baba Memorial Hospital.
    • Gan To Kagaku Ryoho. 2012 Nov 1; 39 (11): 1723-5.

    AbstractWe report a patient who had a complete response by treatment with 200 mg of imatinib mesylate daily for peritoneal recurrences of gastrointestinal stromal tumor(GIST)of the stomach. On March 2007, a 68-year-old woman underwent distal gastrectomy for GIST of the stomach. On May 2007, peritoneal recurrences were recognized on CT scan, and treatment with 400 mg daily of imatinib mesylate was started. Because grade 2 systemic edema and rash developed one week later, the imatinib mesylate dose had to be reduced to 200 mg daily from July 2007. After reduction of imatinib mesylate, the adverse reactions resolved. Peritoneal dissemination disappeared on CT scan from April 2010, and complete response has been maintained for 18 months.

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