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Gan To Kagaku Ryoho · Oct 2014
Review Case Reports[Early diagnosis of capecitabine-induced acute leukoencephalopathy by using diffusion-weighted MRI].
- Rai Shimoyama, Takushiro Ban, Katsunori Miyake, Naoko Isogai, Yuki Ikegaya, Jun Kawachi, Hidemitsu Ogino, and Kazunao Watanabe.
- Dept. of Surgery, Shonankamakura General Hospital.
- Gan To Kagaku Ryoho. 2014 Oct 1; 41 (10): 1251-3.
AbstractA 63-year-old woman with colon cancer who was treated with capecitabine as adjuvant chemotherapy presented with vertigo on day 5, and dysarthria and dysphagia on day 7 of the treatment. Diffusion-weighted magnetic resonance imaging of the brain revealed high signal intensity in the corpus callosum and corona radiata. The patient was diagnosed with acute leukoencephalopathy, and the capecitabine treatment was discontinued. Her symptoms recovered immediately. On the basis of these findings, it can be concluded that diffusion-weighted imaging is useful for the early detection and diagnosis of acute leukoencephalopathy.
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