• Clinical therapeutics · Sep 2018

    Review

    Cannabidiol for Epilepsy: New Hope on the Horizon?

    • Paul E Sanmartin and Kamil Detyniecki.
    • Comprehensive Epilepsy Center, Department of Neurology, Yale University, New Haven, Connecticut. Electronic address: paul.sanmartin@yale.edu.
    • Clin Ther. 2018 Sep 1; 40 (9): 1438-1441.

    AbstractEpilepsy is a common neurologic disorder; it is estimated that ∼50million people are affected worldwide. About one third of those patients are drug resistant, defined as failure to stop all seizures despite adequate trials of at least 2 appropriate medications. There has been an enormous interest in developing antiepileptic drugs with novel mechanisms of action. This review discusses the evidence supporting the anticonvulsant properties of cannabis in humans, focusing on cannabidiol. We begin by exploring the early and somewhat anecdotal evidence that was recently replaced by high-quality data from randomized controlled studies, which subsequently led to the US Food and Drug Administration approval of a purified cannabidiol extract for the treatment of 2 highly refractory pediatric epilepsy syndromes (Dravet and Lennox-Gastaut).Copyright © 2018 Elsevier Inc. All rights reserved.

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