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Frontiers in immunology · Jan 2019
ReviewIs There a Place for Immunotherapy for Metastatic Microsatellite Stable Colorectal Cancer?
- François Ghiringhelli and Jean-David Fumet.
- Department of Medical Oncology, Centre Georges François Leclerc, Dijon, France.
- Front Immunol. 2019 Jan 1; 10: 1816.
AbstractImmunotherapy using checkpoint inhibitor targeting PD-1 and PD-L1 revolutionized the treatment of microsatellite instable metastatic colon cancer. Such treatment is now a standard of care for these patients. However, when used as monotherapy checkpoint inhibitors targeting PD-1 and PD-L1 are not effective in metastatic colorectal cancer patients with microsatellite stable tumors. Recent advances in biology provide a rationale for this intrinsic resistance and support the evaluation of combination therapy to reverse resistance. This article will highlight recent findings on the mechanism of intrinsic resistance and recent advances in clinical trials for combination therapy.
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