• Am. J. Obstet. Gynecol. · Apr 1977

    Randomized Controlled Trial Clinical Trial

    The treatment of dysmenorrhea with naproxen sodium: a report on two independent double-blind trials.

    • M R Henzl, V Buttram, E J Segre, and S Bessler.
    • Am. J. Obstet. Gynecol. 1977 Apr 15; 127 (8): 818-23.

    AbstractThe efficacy of naproxen sodium (naproxen-Na) in dysmenorrhea has been established in two independent double-blind (placebo-controlled) studies. An initial dose of 550 mg. of naproxen-Na was followed by 275 mg. every six hours for a maximum of five days. Twenty patients were included in Study I (10 treated with naproxen-Na) and 23 patients in Study II (12 treated with naproxen-Na). Each patient received the medication during four dysmenorrheic episodes. Thus, a total of 172 treatment courses could be evaluated. A variety of efficacy criteria were measured: frequency of pill intake, changes in pain intensity, the degree of relief achieved by the medication, and need for additional analgesics. In both studies naproxen-Na was demonstrated to be superior to the placebo treatment with high statistical significance in each of these parameters.

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