• Biomed. Pharmacother. · Feb 2019

    Review

    Therapeutic targeting of angiogenesis molecular pathways in angiogenesis-dependent diseases.

    • Asghar Fallah, Ali Sadeghinia, Houman Kahroba, Amin Samadi, Hamid Reza Heidari, Behzad Bradaran, Sirous Zeinali, and Ommoleila Molavi.
    • Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
    • Biomed. Pharmacother. 2019 Feb 1; 110: 775-785.

    AbstractAngiogenesis is a critical step in the progression of almost all human malignancies and some other life-threatening diseases. Anti-angiogenic therapy is a novel and effective approach for treatment of angiogenesis-dependent diseases such as cancer, diabetic retinopathy, and age-related macular degeneration. In this article, we will review the main strategies developed for anti-angiogenic therapies beside their clinical applications, the major challenges, and the latest advances in the development of anti-angiogenesis-based targeted therapies.Copyright © 2018 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

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