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Int. J. Antimicrob. Agents · Oct 2007
Ertapenem for the treatment of extended-spectrum beta-lactamase-producing Gram-negative bacterial infections.
- C P Teng, H H Chen, J Chan, and D C B Lye.
- Department of Pharmacy, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, 308433 Singapore.
- Int. J. Antimicrob. Agents. 2007 Oct 1; 30 (4): 356-9.
AbstractErtapenem is indicated for complicated intra-abdominal, skin and skin-structure, urinary tract and acute pelvic infections as well as community-acquired pneumonia, for which there are cheaper and more narrow-spectrum antibiotics. It is active against extended-spectrum beta-lactamase (ESBL)-producing Gram-negative bacteria, but report of its clinical efficacy is lacking. We evaluated our experience with the use of ertapenem for ESBL-producing Gram-negative bacterial infections over 13 months. Forty-seven patients were treated with 50 courses of ertapenem. Thirty-nine courses were for ESBL-producing Gram-negative bacterial infections, 33% of which were bacteraemia. The clinical response rate was 92% and survival to hospital discharge was 94%. We propose that ertapenem has a role in the first-line treatment of these infections.
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