• Human pathology · Feb 2006

    Review Case Reports

    Splenic small B-cell lymphoma with IGH/BCL3 translocation.

    • Lorinda A Soma, Susanne M Gollin, Ellen D Remstein, Rhett P Ketterling, Heather C Flynn, Kiran K Rajasenan, and Steven H Swerdlow.
    • Division of Hematopathology, University of Pittsburgh School of Medicine, PA 15213, USA.
    • Hum. Pathol. 2006 Feb 1; 37 (2): 218-30.

    AbstractIsolated chromosomal translocations are important defining features of many non-Hodgkin lymphomas, especially of B-cell type. In contrast to some other translocations, the significance of IGH/BCL3 translocations is not well defined. Although often considered a feature of the ill-defined entity atypical chronic lymphocytic leukemia, very few cases are reported in which involvement of BCL3 and the precise B-cell neoplasm are both well documented. For this reason, we report a splenic-based CD5(-), CD10(-), CD43(-), CD23(-), CD103(-), FMC7(+), CD25(+) small B-cell lymphoma associated with epithelioid histiocyte clusters and a t(14;19)(q32;q13) representing an IGH/BCL3 translocation based on classical cytogenetic studies, chromosomal painting, and fluorescence in situ hybridization studies. The previously reported neoplasms with t(14;19)(q32;q13) or IGH/BCL3 translocations are also reviewed. The present case did not fall into any of the classic B-cell lymphoma categories and clearly did not represent chronic lymphocytic leukemia/small lymphocytic lymphoma. This case suggests that the IGH/BCL3 translocation may help to define a new clinicopathologic entity.

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