• Shinji Kurosaka, Takefumi Satoh, Edward Chow, Yuji Asano, Ken-ichi Tabata, Masaki Kimura, Hideyasu Tsumura, Kazumasa Matsumoto, Hiromichi Ishiyama, Yusuke Inoue, Kazushige Hayakawa, and Shiro Baba.
• Department of Urology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
• Ann Nucl Med. 2012 Jul 1; 26 (6): 485-91.

PurposeApproximately 80% of patients with prostate cancer will develop bone metastases, which often lead to bone pain and skeletal-related events. Sr-89 is an established alternative for the palliation of bone pain in prostate cancer. We aimed to assess the effect of Sr-89 radionuclide therapy on quality of life (QOL) in prostate cancer patients with painful bone metastases.Materials And MethodsThirteen patients received a single intravenous injection of Sr-89 at a dose of 2.0 MBq/kg. All patients underwent QOL evaluation prior to Sr-89 treatment and 1, 2, and 3 months afterward using the Japanese version of the EORTC QLQ-BM22, EORTC QLQ-C30, a VAS, and face scale. We also evaluated PSA and ALP response and toxicity of the Sr-89 therapy.ResultsThe pain characteristics subscale of the EORTC QLQ-BM22 was significantly reduced from 1 month onward compared with the baseline. The functional interference and psychosocial aspects subscales were significantly higher than baseline from 2 months onward. At 2 months, VAS indicated a significant reduction in pain as compared to the baseline. Sr-89 therapy caused a nonsignificant reduction in PSA and ALP levels. No patients had leukocyte toxicity, and one patient had grade 3 platelet toxicity.ConclusionSr-89 radionuclide therapy can provide not only reduced pain characteristics but also better psychosocial aspects and functional interference in patients with painful bone metastases of prostate cancer.

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