• Asia Pac J Clin Nutr · Jan 2016

    Review Meta Analysis

    Coffee consumption and risk of gastric cancer: an updated meta-analysis.

    • Yan Xie, Shifeng Huang, Tongchuan He, and Yuxi Su.
    • Department of Laboratory Medicine, Chongqing Key Laboratory of Pediatrics, Ministry of Education Key Laboratory of Child Development and Disorders, the Children's Hospital of Chongqing Medical University, Lab medicine of Yubei Maternity and Children Care Hospital, China International Science and Technology Cooperation base of Child development and Critical Disorders, Chongqing, China.
    • Asia Pac J Clin Nutr. 2016 Jan 1; 25 (3): 578-88.

    Background And ObjectivesCoffee is one of the most widely consumed beverages worldwide, and many studies have investigated the association between coffee consumption and gastric cancer. However, the results are inconsistent. We conducted a systematic analysis of relevant population studies to derive a more precise estimation.Methods And Study DesignCochrane library, PubMed and Embase databases were searched to identify studies that met predetermined inclusion criterion through July 2014. All epidemiologic studies regarding coffee consumption and gastric cancer risk were selected, and relative risks (RRs) with 95% confidence intervals (CIs) were calculated.ResultsTwenty two studies (9 cohort and 13 case-control studies) involving 7,631 cases and 1,019,693 controls were included. The summary RR of gastric cancer was 0.94 (95% CI: 0.80-1.10) for the highest category of coffee consumption compared with the lowest category, and 0.93 (95% CI: 0.88-0.99) for coffee drinkers compared with nondrinkers. We stratified the population by coffee consumption. The pooled RR for the population with <1 cup/day, 1-2 cups/day and 3-4 cups/day coffee consumption compared with nondrinkers were 0.95 (95% CI: 0.84-1.08), 0.92 (95% CI: 0.82-1.03) and 0.88 (95% CI: 0.76-1.02), respectively, indicating that an increase in coffee consumption was associated with a decreased risk of gastric cancer. Furthermore, we stratified the studies by design, sex, population and time. A significant association between coffee intake and decreased gastric cancer risk was shown in case-control studies (RR=0.85, 95% CI: 0.77-0.95) and among the studies published over the last ten years (RR=0.88, 95% CI: 0.77-1.00).ConclusionsOur meta-analysis suggested that coffee consumption might be associated with a decreased risk of gastric cancer.

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