• Expert Rev Anticancer Ther · May 2008

    Review

    Immunotherapy against angiogenesis-associated targets: evidence and implications for the treatment of malignant glioma.

    • Richard G Everson, Michael W Graner, Matthias Gromeier, James J Vredenburgh, Annick Desjardins, David A Reardon, Henry S Friedman, Allan H Friedman, Darell D Bigner, and John H Sampson.
    • Division of Neurosurgery, Department of Surgery, Box 3050 Med Ctr, Preston Robert Tisch Brain Tumor Center at Duke University, Durham, NC 27710, USA. richard.everson@duke.edu
    • Expert Rev Anticancer Ther. 2008 May 1; 8 (5): 717-32.

    AbstractAngiogenesis, the growth of new blood vessels from previously existing vasculature, is a requirement for tumor growth and metastasis. The first US FDA-approved drugs targeting angiogenesis have shown potential in the treatment of malignant gliomas. Immunotherapy as a treatment modality lends itself well to specifically targeting angiogenesis in tumors and may represent a powerful tool in the treatment of malignant gliomas. This review focuses on developments in immunotherapy targeting angiogenesis and tumor-vascular-specific endothelial cells using a variety of immunotherapeutic strategies including monoclonal antibodies and conjugated immunotoxins, as well as cellular, peptide, DNA and dendritic cell vaccines.

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