• FooThomas K FTKMagnetic Resonance Imaging Laboratory, GE Global Research, Niskayuna, New York, USA. thomas.foo@research.ge.com, Glenn S Slavin, David A Bluemke, Marcela Montequin, Maureen N Hood, and Vince... more nt B Ho. less
• Magnetic Resonance Imaging Laboratory, GE Global Research, Niskayuna, New York, USA. thomas.foo@research.ge.com
• J Magn Reson Imaging. 2007 Oct 1; 26 (4): 927-33.

PurposeTo develop a method for fat suppression in myocardial delayed enhancement (MDE) studies that achieves effective signal intensity reduction in fat but does not perturb myocardial signal suppression.Materials And MethodsA new approach to fat suppression that uses a spectrally-selective inversion-recovery (SPEC-IR) tip-up radio frequency (RF) pulse following the conventional nonselective IR RF pulse together with a second SPEC-IR RF pulse is proposed. The tip-up pulse restores the fat longitudinal magnetization after the nonselective IR pulse and allows the fat magnetization to recover more fully toward its equilibrium value, providing for better fat suppression by the second SPEC-IR RF pulse. This new approach was validated in phantom studies and in five patients.ResultsEffective fat suppression was achieved using the proposed technique with minimal impact on normal myocardial signal suppression. Mean fat suppression achieved using this approach was 67% +/- 8%, as measured in the chest wall immediately opposite the heart.ConclusionThe results indicate this modular-type approach optimizes fat suppression in myocardial delayed enhancement studies but does not perturb the basic IR pulse sequence or change basic acquisition parameters.(c) 2007 Wiley-Liss, Inc.

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