• J. Am. Acad. Dermatol. · May 2001

    Case Reports

    Skin and nail changes in children with sickle cell anemia receiving hydroxyurea therapy.

    • E E O'branski, R E Ware, N S Prose, and T R Kinney.
    • Duke University Pediatric Sickle Cell Program and Division of Hematology/Oncology, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA.
    • J. Am. Acad. Dermatol. 2001 May 1; 44 (5): 859-61.

    AbstractSkin and nail changes from long-term hydroxyurea therapy are reported in adults. Skin and nail changes, including nail hyperpigmentation, longitudinal bands, and hyperpigmentation of the palms and other skin surfaces, developed in 7 children with sickle cell anemia after 6 to 16 weeks of hydroxyurea therapy. Cutaneous and nail changes may occur in children receiving hydroxyurea.

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