• Ann. Oncol. · Jan 2021

    Review

    Side-effect management of chimeric antigen receptor (CAR) T-cell therapy.

    • M-L Schubert, M Schmitt, L Wang, C A Ramos, K Jordan, C Müller-Tidow, and P Dreger.
    • Department of Medicine V, University Hospital Heidelberg, Heidelberg, Germany. Electronic address: maria-luisa.schubert@med.uni-heidelberg.de.
    • Ann. Oncol. 2021 Jan 1; 32 (1): 34-48.

    AbstractChimeric antigen receptor (CAR) T cells directed against the B-cell marker CD19 are currently changing the landscape for treatment of patients with refractory and/or relapsed B-cell malignancies. Due to the nature of CAR T cells as living drugs, they display a unique toxicity profile. As CAR T-cell therapy is extending towards other diseases and being more broadly employed in hematology and oncology, optimal management strategies of side-effects associated with CAR T-cell therapy are of high relevance. Cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS), and cytopenias constitute challenges in the treatment of patients with CAR T cells. This review summarizes the current understanding of CAR T-cell toxicity and its management.Copyright © 2020 European Society for Medical Oncology. All rights reserved.

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