• Am. J. Physiol. Lung Cell Mol. Physiol. · Oct 2016

    There is blood in the water: hemolysis, hemoglobin, and heme in acute lung injury.

    • Amit Gaggar and Rakesh P Patel.
    • Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama; Medicine Service, Birmingham VA Medical Center, Birmingham, Alabama.
    • Am. J. Physiol. Lung Cell Mol. Physiol. 2016 Oct 1; 311 (4): L714-L718.

    AbstractThe major role of red blood cells (RBCs) is to deliver oxygen and remove carbon dioxide within organisms through the unique properties of hemoglobin. Although beneficial within RBCs, when outside hemoglobin and its breakdown products (heme, iron) induce proinflammatory responses affecting various cellular responses. Although these effects are considered to be prominent in disorders with increased hemolysis, recent evidence suggests that this process may be active in nonhemolytic disorders such as acute lung injury/acute respiratory distress syndrome. This perspectives article focuses on data related to red cell products in nonhemolytic disorders and the potential to target these factors in acute lung injury/acute respiratory distress syndrome.Copyright © 2016 the American Physiological Society.

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