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- T van Meerten and A Hagenbeek.
- Department of Haematology, University Medical Centre Utrecht, Utrecht, the Netherlands.
- Neth J Med. 2009 Jul 1; 67 (7): 251-9.
AbstractTargeting the CD20 antigen on B lymphocytes with the monoclonal antibody rituximab has greatly improved the outcome of patients with B-cell malignancies. Despite the success of rituximab, resistance occurs in about half of the patients, resulting in non-response to treatment or early relapse of the original disease. A better understanding of the mechanism of rituximab resistance has lead to the development of novel, improved anti-CD20 antibodies. This review describes the development of CD20-targeted therapy from its historical background towards the next generation of anti-CD20 monoclonal antibodies and explains new strategies to overcome resistance.
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