• Trends Pharmacol. Sci. · Nov 2007

    Review

    CGRP antagonists: unravelling the role of CGRP in migraine.

    • Henri Doods, Kirsten Arndt, Klaus Rudolf, and Stefan Just.
    • Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach, Germany. henri.doods@boehringer-ingelheim.com
    • Trends Pharmacol. Sci. 2007 Nov 1; 28 (11): 580-7.

    AbstractMigraine is a complex, debilitating neurovascular disorder. Although knowledge on the main molecular players is still incomplete, recent preclinical and clinical findings indicate that there is a clear correlation between migraine-associated headache and the release of the neuropeptide calcitonin gene-related peptide (CGRP). BIBN4096 was the first CGRP antagonist to be tested in clinical trials for the treatment of migraine. The proven efficacy of this agent, and also the CGRP antagonist MK-0974, to alleviate acute migraine headache provided significant support for the hypothesis that CGRP has an important role in migraine pathophysiology. Moreover, the recently published results from Phase II trials are encouraging and suggest that this new type of drug might offer advantages over existing therapies for patients suffering from migraine and related headaches.

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