-
Multicenter Study
Chemotherapy: How useful is adjuvant irinotecan in stage IV CRC?
- Fotios Loupakis and Alfredo Falcone.
- Division of Medical Oncology, Department of Oncology, Transplants and New Technologies in Medicine, University of Pisa, Pisa, Italy.
- Nat Rev Clin Oncol. 2010 Apr 1; 7 (4): 190-1.
AbstractPatients who undergo hepatic surgery for initially resectable liver metastases from colorectal cancer have a 70% risk of relapse. a recent phase III randomized trial has failed to demonstrate an improvement in disease-free survival with the addition of irinotecan to 5-fluorouracil and folinic acid as adjuvant treatment for patients with radically resected colorectal cancer with liver metastases.
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