• Beatriz Duarte Palma, Paula Ayako Tiba, Ricardo Borges Machado, Sergio Tufik, and Deborah Suchecki.
• Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
• Rev Bras Psiquiatr. 2007 May 1;29 Suppl 1:S33-8.

ObjectiveTo review the literature on the interaction between sleep and the immune system.MethodA search on Web of Science and Pubmed database including the keywords sleep, sleep deprivation, stress, hypothalamic-pituitary-adrenal axis, immune system, and autoimmune diseases.ResultsOn Web of Science, 588 publications were retrieved; 61 references, more significant and closer to our objective, were used, including original articles and review papers.ConclusionSleep deprivation and immune system exert a bidirectional influence on each other. Since sleep deprivation is considered a stressor, inasmuch as it induces elevation of cortisol or corticosterone levels in humans and rodents, respectively, and given the well-known immunosuppressive effect of glucocorticoids, we propose that increased activation of the hypothalamic-pituitary-adrenal axis is a major mediator of the immune alterations observed in patients with insomnia or in sleep deprived subjects.

30 keywords...

hide…