• World J. Gastroenterol. · May 2014

    Review

    Should capecitabine replace 5-fluorouracil in the first-line treatment of metastatic colorectal cancer?

    • Carlos Aguado, Beatriz García-Paredes, Miguel Jhonatan Sotelo, Javier Sastre, and Eduardo Díaz-Rubio.
    • Carlos Aguado, Beatriz García-Paredes, Miguel Jhonatan Sotelo, Javier Sastre, Eduardo Díaz-Rubio, Department of Medical Oncology, Hospital Clínico San Carlos, 28040 Madrid, Spain.
    • World J. Gastroenterol. 2014 May 28; 20 (20): 6092-101.

    AbstractFluoropyrimidines play a central role in the first-line treatment of metastatic colorectal cancer. Our aim was to review whether capecitabine was a safer, non-inferior, economically superior and more convenient alternative to 5-fluorouracil. Capecitabine has previously been compared to 5-fluorouracil-either as a monotherapy or in combination with oxaliplatin, irinotecan, or biological drugs-and has been found to have comparable efficacy and safety profiles. Furthermore, pharmacoeconomic data and patients' preferences for oral chemotherapy further favor capecitabine. Therefore, capecitabine appears to be an effective and safe alternative to fluorouracil in the first-line treatment of metastatic colorectal cancer.

      Pubmed     Free full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…