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Cancer treatment reviews · Nov 2010
ReviewUpdate on capecitabine alone and in combination regimens in colorectal cancer patients.
- N Silvestris, E Maiello, F De Vita, S Cinieri, D Santini, A Russo, S Tommasi, A Azzariti, G Numico, S Pisconti, D Petriella, V Lorusso, A Millaku, and G Colucci.
- Medical Oncology Department, National Cancer Institute Giovanni Paolo II, via Hahnemann 10, Bari, Italy. n.silvestris@oncologico.bari.it
- Cancer Treat. Rev. 2010 Nov 1; 36 Suppl 3: S46-55.
AbstractCapecitabine is an orally administered fluoropyrimidine carbamate which has been developed as a prodrug of 5-FU with the goal to improve its tolerability and intratumoral drug concentration. The review aims to provide an evidence-based update of clinical trials investigating the clinical efficacy, adverse-event profile, dosage and administration of this drug, alone or in combination with conventional chemotherapeutics and/or new target-oriented drugs, in the management of colorectal cancer patients.Copyright © 2010 Elsevier Ltd. All rights reserved.
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