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Neuroscience letters · Feb 2004
Peri-sciatic administration of indomethacin early after nerve injury can attenuate the development of tactile allodynia in a rat model of L5 single spinal nerve injury.
- Masahiro Takahashi, Masahiko Kawaguchi, Keiji Shimada, Noboru Konishi, Hitoshi Furuya, and Toshikatsu Nakashima.
- Department of Pharmacology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan.
- Neurosci. Lett. 2004 Feb 6; 356 (1): 37-40.
AbstractTo clarify the role of cyclooxygenase in the peripheral nerve on the development of neuropathic pain, we investigated the effects of peri-sciatic administration of indomethacin on the development of allodynia in a model of L5 single spinal nerve injury. Peri-sciatic administration of indomethacin (1 mg/kg) was performed 3, 24, or 72 h after nerve injury (n=6/each). In rats with indomethacin 3 or 24 h after nerve injury, ipsi-lateral paw withdrawal thresholds 7-35 days after nerve injury were significantly higher compared with those in the control group (n=6: without peri-sciatic treatment) (P<0.05). However, such efficacy was no longer apparent when indomethacin was administered 72 h after nerve injury. These results suggest that peri-sciatic administration of indomethacin early (less than 24 h) after nerve injury can attenuate the development of allodynia.
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