• Brain pathology · Jan 2008

    Review

    MicroRNAs: biogenesis and molecular functions.

    • Xuhang Liu, Kristine Fortin, and Zissimos Mourelatos.
    • Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
    • Brain Pathol. 2008 Jan 1; 18 (1): 113-21.

    AbstractSmall regulatory RNAs are essential and ubiquitous riboregulators that are the key mediators of RNA interference (RNAi). They include microRNAs (miRNAs) and short-interfering RNAs (siRNAs), classes of approximately 22 nucleotide RNAs. miRNAs and siRNAs bind to Argonaute proteins and form effector complexes that regulate gene expression; in animals, this regulation occurs primarily at the post-transcriptional level. In this review, we will discuss our current understanding of how miRNA and siRNAs are generated and how they function to silence gene expression, focusing on animal and, in particular, mammalian miRNAs.

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