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Immunol Allergy Clin North Am · Nov 2018
ReviewMolecular Endotypes Contribute to the Heterogeneity of Asthma.
- Erwin W Gelfand and Michaela Schedel.
- Division of Cell Biology, Department of Pediatrics, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA.
- Immunol Allergy Clin North Am. 2018 Nov 1; 38 (4): 655-665.
AbstractDiagnosis and management of asthma is commonly implemented based on clinical assessment. Although these nonmolecular biomarkers have been useful, limited resolution of the heterogeneity among asthmatic patients and little information regarding the underlying pathobiology of disease in individuals have been provided. Molecular endotying using global transcriptome expression profiling associated with clinical features of asthma has improved our understanding of disease mechanisms, risk assessment of asthma exacerbations, and treatment responses, especially in patients with type 2 inflammation. Further advances in establishing pathobiological subgroups, bioactive pathways, and true disease endotypes hold potential for a more personalized medical approach in asthmatic patients.Copyright © 2018 Elsevier Inc. All rights reserved.
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