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J. Infect. Chemother. · Apr 2012
Bactericidal activity of topical antiseptics and their gargles against Bordetella pertussis.
- Takahisa Suzuki, Hiroshi Kataoka, Takashi Ida, Kazunari Kamachi, and Takeshi Mikuniya.
- Pharmaceutical Research Center, Meiji Seika Pharma Co., Ltd., Yokohama, Japan. takahisa.suzuki@meiji.com
- J. Infect. Chemother. 2012 Apr 1; 18 (2): 272-5.
AbstractBordetella pertussis is the etiological agent of whooping cough, a common cause of respiratory illness in both children and adults. In the present study, we investigated the bactericidal activity of four antiseptics-povidone-iodine (PVP-I), benzethonium chloride (BEC), chlorhexidine gluconate (CHG) and benzalkonium chloride (BAC)-against B. pertussis ATCC9797 and clinical isolates. Among the topical antiseptics, PVP-I, BEC, and BAC, PVP-I and BAC in particular, showed high bactericidal activity, whereas CHG had low activity. PVP-I gargle also showed high bactericidal activity, similar to topical PVP-I. However, BEC gargle had low bactericidal activity. Our results indicate that topical PVP-I and BAC, and PVP-I gargle would be useful as effective antiseptics against B. pertussis.
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